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Description
doi: 10.1038/cmi.2017.138
Large to small mutations at the two positions allowed the incorporation of substituted 382 , including, ( S )- meta -nitro--phenylalanine, ( S )- meta -cyano--phenylalanine, ( S )- ortho -methyl--phenylalanine and ( S )- ortho -bromo--phenylalanine
inhibition of sirtuins activity leading to an increased production of RONS by SOD inhibition, a proinflammatory state by preventing their inhibition of tumor necrosis factor alpha (TNF) and NFB, and tumorigenic effect by preventing their inhibitory effect on c-Jun and c-Myc
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