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Daratumumab earned approval for monotherapy due to its efficacy, safety profile and durable responses demonstrated in the phase 1/2 GEN501 and the phase 2 SIRIUS clinical trials on heavily pretreated RRMM patients [71, 72]
Liu W, Wang M, Wang M, Liu M

In addition to HMGCR impairment, statins also alter differentiation of white blood cells in T helper1 and T helper17 phenotypes, resulting in development of regulatory T cells which express the Foxp3 transcription factor in vitro and in vivo [64]

[DOI] [PubMed] [Google Scholar] 190.Feher J., Kovacs B., Kovacs I., Schveoller M., Papale A., Balacco Gabrieli C
