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YY: Conceptualization, Investigation, Validation, Writing review & editing
For assessment of treatment response in rats bearing orthotopic U251 tumors, TMZ was administered intraperitoneally at a dose of 50 mg/kg in 20% DMSO in saline when tumors reached a volume of 0.27 0.05 cm 3

Principal component analysis (PCA) was performed using metaX package
