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Less prevalence is observed amongst the least developing nations indicating that lifestyle and diet play a major role in development of the disease as observed amongst the developed nations

Pharmacological therapies targeting GPX4 are a promising strategy for inducing ferroptosis in cancer cells, including clear-cell carcinomas that resistant to conventional treatments [49]

106 RiquelmeE.ZhangY.ZhangL.MontielM.ZoltanM.DongW.et al (2019)

Overexpression of G6PD led to the following changes in cells exposed to high glucose as compared to cells exposed to high glucose with wild type G6PD activity: B: G6PD activity was increased