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The answer comes down to concentration

Notch signaling is also considered a key player in carcinogenesis, acting as either an oncogene or a tumor suppressor in various malignancies, including different TC histotypes, thus suggesting that its apparent dual role is cell type and context-dependent [152,153]

As it is not only a challenge physically, but one that also affects mental health and well-being, and points to an increased risk of cardiovascular disease in the future, it is a condition that should receive holistic treatment that considers the many contributing factors

Garweg JG, Tappeiner C, Halberstadt M (2013) Pathophysiology of proliferative vitreoretinopathy in retinal detachment