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Due to its hygroscopic nature, temporary water retention may occur initially (related to the osmotic pressure effect of creatine entering cells), but no other serious adverse reactions are observed

Some medical professionals prescribe L-carnitine in supplement form to help support those with heart conditions, diabetes, erectile dysfunction, and other health conditions

Klusa VZ, Isajevs S, Svirina D, Pupure J, Beitnere U, Rumaks J, Svirskis S, Jansone B, Dzirkale Z, Muceniece R, Kalvinsh I, Vinters HV (2010) Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease

These effects are usually mild and disappear with dosage adjustment