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However, further studies are needed to clarify the exact mechanism by which KD affects NAD + /NADH levels

When examining perfused liver tissue, the contribution of the ER to total ROS production is negligible, while peroxisomes emerge as a prime ROS production site

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Additionally, mtDNA damage has been associated with PD etiology and progression (Tresse et al., 2023) and mitochondrial dysfunction is linked genetically to PD, since many mutations associated to familial cases of PD were found in genes such as PINK1 or PARKIN, which regulate mitochondrial turnover (Valente et al., 2004