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The first evidence showing APP overexpression in DS was demonstrated within enlarged endosomes and lysosomes, where APP accumulation could be initiated at the fetal stage, as early as 28 wk of gestation (465)

Kroemer, was previously employed by Sanofi and currently consults for Boehringer Ingelheim

In a rat streptozotocin-induced model of brain hypoglycemia, ALCAR attenuated both the streptozotocin-induced impairment in spatial discrimination learning and decrease in hippocampal choline acetyltransferase activity (Prickaerts et al., 1995)

Aquac Res 52:10461062 Du ZY, Ma T, Liaset B, Keenan AH, Araujo P, Lock EJ, Madsen L (2013) Dietary eicosapentaenoic acid supplementation accentuates hepatic triglyceride accumulation in mice with impaired fatty acid oxidation capacity