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FUNDING INFORMATION This work was supported by the Medical Science and Technology Project of Zhejiang Province (grant number 2022KY506), the National Natural Science Foundation of China (grant number 81901273), and the Science Technology Department of Zhejiang Province (grant number Q21H090076)

Data Availability Statement The data associated with this paper are available upon request to the corresponding author

The result of such interactions are mutations and inactivation of various metabolic pathways
