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Thus, by promoting intimal hyperplasia, these vascular disorders (which are related to smooth muscle cell proliferation, collagen accumulation, and the extracellular matrix modification that may result from homocysteinylation of the vascular wall structure leading to connective tissue deterioration) might contribute to the atherogenic tendency of hyperhomocysteinemia

Role of mast cells Mast cells and macrophages act by releasing interleukins (IL-1, IL-6, IL-12, IL-15, IL-18, IL-23), TNF-, reactive nitrogen and oxygen species, phagocytosis and antigen presentation, production of matrix-degrading enzymes and prostanoids (Shichita et al

Moreover, melanoma cells recruit immunosuppressive regulatory Treg cells through secreting relevant chemokines, and inhibit the natural cytotoxicity of NK cells against tumor cells through metabolic reprogramming

Elsevier Masson SAS
