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These studies are mechanistically aligned with the VEGFR2/eNOS in vitro findings but rely on the same originating laboratory and rodent model system, and independent replication outside that network is sparse

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To perturb the newly-emerged TNR epitopes, cultured neurons or organotypic hippocampal slices cultures were blocked for 2 h with 1:100 unlabeled TNR antibodies (neurons) or 50 g/mL unlabeled Fab fragments directed against TNR (organotypic slices), together with 1 mg/mL unlabeled FluoTag-X2 anti-mouse secondary nanobodies

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Budesonide has a better safety profile than Fluticasone for pneumonia risk and should be preferred, but the dose should be kept to its minimum, and whenever possible should be withdrawn

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