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Description
TP53 is recognized to mediate its tumor-suppressive functions by adjusting the expression of genes that promote cell cycle arrest, apoptosis, and senescence (156)
doi: 10.1039/D3TB01076G
The p53 gene, known for its tumor-suppressive properties, modulates the phosphorylation of the RB protein by influencing cyclin-dependent kinases (CDKs), thereby regulating the E2F family of transcription factors, which are integral to the progression of the cell cycle
The protein transport protein Sec63 further drives lipogenesis by stabilizing ACLY, thereby increasing acetyl-CoA production [165]
