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Additionally, by blocking Toll-like receptor 4, naltrexone may also alleviate neuroinflammation in ME/CFS [149]

These results suggest that the KI mutation confers a hypersecretory CCK phenotype under stress, which may underlie the heightened anxiety susceptibility observed in this model

Because of the theoretical benefits of maintaining antioxidant defenses to combat various acute and chronic diseases, reducing the consequences of aging and reducing tissue damage from exposure to environmental oxidants, therapeutic approaches to increase systemic and/or tissue-specific glutathione concentrations are of considerable investigational interest

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