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In individuals with diabetes, B-vitamin deficiencies may occur due to increased urinary excretion and impaired absorption

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Low levels of L-carnitine synthesis may make supplementation of L-carnitine beneficial to chick embryos

Reduced expression of mutant SOD1 in microglia delayed late disease progression and increased survival of SOD1 G37R mice (Boille et al., High calorie diets in ALS A number of studies have tried to correct the energy deficit using metabolic therapies in animal models and patients with ALS, with the hope that an improved metabolism can delay symptoms and extend survival in ALS (Dupuis et al., 2004