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The BSeC@MSNs-RGD with PEI coating was found to cross the BBB and disrupt brain cancer U87 VM channels and displayed inhibitory effects on the U87 tumor, therefore validating its anticancer efficacy in vivo

Lysosomal membrane damage occurs along a continuum, ranging from subtle lipid packing defects and ion leakage to progressive membrane ruptures and, eventually, irreversible permeabilization 1,6

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While conventional ILMs consist of an organic cation and an organic or inorganic anion, CHCA-derived ILMs allow the incorporation of amines, pyridines, imidazoles, and aminoquinolines as cation donors