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MiR-10b was proven to inhibit the pro-apoptotic BIM, a Bcl-2 family member, and results in the chemoresistance of 5-FU in CRC cells (Nishida et al., 2012)

Numerous studies have provided evidence of the protective effects of natural polyphenolic substances such as resveratrol, quercetin, curcumin, and fisetin, and of natural non-polyphenolic substances such as berberine (McCubrey et al., 2017)

CD8 + T CELL EFFECTOR FUNCTION AND MEMORY Immunologic memory is a primary feature of the adaptive immune response and the biological basis for vaccination

Discussion: These findings highlight curcumin's potential in alleviating DACD