Intercellular antioxidant support
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Description
In addition, dysregulated mitochondrial biogenesis and excessive ATP release under oxidative conditions act as damage-associated molecular patterns (DAMPs), activating inflammasomes and enhancing chemotactic signals for immune cells like CD8 + T cells 67
The NADase CD38 is involved in the immune response by producing second messengers ADPR, 20-deoxy-ADPR (2dADPR), NAADP, and cADPR
The release of mtDNA is another inflammation mechanism correlated with the onset of multi-organ failure in acute respiratory distress patients [242]
[DOI] [PubMed] [Google Scholar] 664
