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While there is still a lot that researchers dont know here, it looks like the SOD1 mutations cause a gain-of-function and altered folding in a way that causes a loss of motor neuron function.[ref] SOD1 Genotype Report: SOD1 genetic variants can cause either an increase or a decrease in enzyme activity
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doi: 10.1097/00001756-199810260-00031 183 ChezMGBuchananCPAimonovitchMCBeckerMSchaeferKBlackCet al
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