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FIGURE 4 According to the World Health Organization (WHO), epidemiological evidence indicates that in pregnant women, a caffeine intake of 300 mg/day (5 mg/kg day) is associated with an increased risk of intrauterine growth retardation (IUGR) ( via impacting histone acetylation and cholesterol synthesis-related gene expression via regulation of the A2AR/cAMP/PKA pathway and SIRT1 expression at the cellular level (Voerman et al., 2020)
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Chu J, Tu Y, Chen J, Tan D, Liu X, Pi R
On the other hand, vitamin B12 plays a crucial role in maintaining healthy nerve function, and its deficiency can also lead to neuropathy
