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For Cu-Zn-SOD, the catalytic site is the tetracoordinate structure of copper ion (Cu 2+ ) with four imidazolyls of histidine residues 14,15,16 , and the coordinated zinc ion (Zn 2+ ) plays the role in maintaining structural integrity 17,18,19

NNMT (nicotinamide N-methyltransferase) is a cytosolic enzyme that catalyzes a specific methylation reaction: it transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing two products 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

And so things like curcuminturmeric things like green tea or blueberries, these antioxidants are very helpful in this process

Neither supplement works miracles