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During oocyte meiosis, coordinated Ca 2+ release from the ER to mitochondria through the MAMs region is essential for Ca 2+ oscillations, which serve as key signals for cytoplasmic maturation, spindle reorganization, and chromosome alignment [64, 65]

Clinically, gut microbiota-derived BCAAs synergize with PD-1 inhibitors to improve therapeutic responses in non-small cell lung cancer (NSCLC), potentially through microbiota-driven expansion of peripheral Tm cells and natural killer (NK) cell activation (Yao et al., 2023

10.1038/nature742 43 EzikeT

This may explain a crucial role for activating Met mutations, although their frequency in primary tumors seems to be very low (29)