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Recently, it has also been found that IN administration insulin and IGF1 promoted survival of IS animals [237, 301, 302]
Western blot analysis revealed suppression of TNF-, COX-2, and nitric oxide synthase protein expression, indicating effective inhibition of inflammation-related signaling pathways
Oertel W, Eggert K, Pahwa R, Tanner CM, Hauser RA, Trenkwalder C, Ehret R, Azulay JP, Isaacson S, Felt L, Stempien MJ
9,37 However, the low nasal cavity volume poses a challenge for drugs with poor aqueous solubility or those administered at high doses
