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The steric hindrance introduced by the brush-like PEG molecules from the surface of the nanoparticles can result in prolonged residence time in the circulation of the nanoparticles, and potential accumulation to specific tissues, such as tumors, due to the enhanced permeation and retention effect (EPR) (Lahooti et al., 2023)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Wang Y, Korman SH, Ye J, Gargus JJ, Gutman A, Taroni F, Garavaglia B, Longo N

Consistent Use (Refills): The clinic tracked prescription refill rates as a surrogate for efficacy/satisfaction