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The cellular autophagy induced by the overproduction of intracellular ROS and the starvation effect of 3BP exhibited a pro-death effect, further optimized the final outcome of RT

Although CDO possessed appreciable catalytic activity in the absence of the Cys-Tyr cofactor, cofactor formation increased CDO catalytic efficiency by ~10-fold (e.g., 3,200 M 1 s 1 for wild-type CDO versus 220 M 1 s 1 for Cys93Ser mutant CDO, which lacks the Cys residue needed for formation of the Cys-Tyr cofactor)

doi: 10.3389/fendo.2021.767785

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