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Interestingly, preclinical data has suggested that compounds thought to target downstream processes of ATXN3 aggregation have also an effect on the primary loss of PQC mechanisms, namely citalopram, creatine, and trehalose, making them great contenders for translation [148, 164, 236]

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The study began by collecting blood samples from the jugular veins of fourth-month old, male Sprague-Dawley rats

155 The multi-nutrient tablet provided: In an uncontrolled clinical trial that included 31 participants with one-sided tinnitus, 18 weeks of treatment with a multi-nutrient supplement, providing glycerophosphorylcholine (55 mg/day), glycerophosphorylethanolamine (45 mg/day), beta-carotene (6,000 mcg RAE/day), vitamin C (180 mg/day), and vitamin E (10 mg/day), led to reductions in tinnitus loudness and discomfort