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Studies of carbonyl sulfide toxicity: Metabolism by carbonic anhydrase

showed that cholesterol crystals serve as DAMPs and cause the activation of the NLRP3 [nucleotide-binding domain leucine-rich repeat containing (NLR) family, pyrin domain containing 3] inflammasome in macrophages (Rajamaki et al., 2010)

JP patent 61,192,282 Kohjin Co

We further confirmed their expression by western blotting, thus validating the nascent RNA-profiling results