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Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect

Consistent administration produces better results than inconsistent dosing, so establish routines to minimize missed doses

(2) M Heffernan, R J Summers, A Thorburn, E Ogru, et al (2001) The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice Endocrinology, 2001 Dec, Volume 142 (Issue 12), Pages 5182-9

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