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Abstract T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I)

The NRF2 and NRF1 pathways regulate GPX4 expression, with NRF2 downregulation elevating GPX4 levels and NRF1 enhancing GPX4 expression to inhibit ferroptosis

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