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For example, the delineation of sub-cellular folate and one-carbon metabolism in mitochondria and the nucleus (8), the importance of formate in said metabolism (9, 10), identification of the transcobalamin receptor by which vitamin B12 is taken up into cells (11), and delineation of the sequence of events underlying intracellular vitamin B12 processing (1214)

That creates confusion for people trying to separate marketing hype from actual science