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Metabolism & Elimination PT-141 undergoes metabolism primarily through hydrolysis of peptide bonds , a typical degradation pathway for peptide therapeutics
37,38 In a small cohort of 14 children with UCDs, Lichter-Konecki et al reported a faster reduction of ammonia blood level in patients treated with CVVHD and maintained hypothermic when compared to patients treated with CVVHD and maintained normothermic
Briefly, the cells were stained with BODIPY 493/503 and Hoechst 33342 at room temperature for 20 min, followed by imaging using a fluorescence microscope (Nikon Ds Ri2, Japan)
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