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Using in vitro tag-free mature AIF-based biochemical assays, cellular loss-of-function and gain-of-function studies, and AIF3 splicing models in vivo, we further found that full-length mature AIF was a mammalian mitochondrial complex I alternative NAD(P)H dehydrogenase and possessed previously unrecognized glutathione reductase (GR) activity, whereas AIF3 lost GR and NAD(P)H dehydrogenase activities

A., Loebig T

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, et al

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