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Hyperglycemia, commonly associated with obesity and insulin resistance, exacerbates OS through multiple metabolic pathways including the activation of the polyol and hexosamine (maladaptive glucose metabolism) pathways, converging on protein kinase C (PKC) signalling, and augmented mitochondrial oxidative phosphorylation, all of which increase ROS production [54]

Sun W, Zou Y, Cai Z, Huang J, Hong X, Liang Q, Jin W (2022) Overexpression of NNMT in glioma aggravates tumor cell progression: an emerging therapeutic target