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Such trials should consider phenotype-stratified populationsfor example, insulin-resistant versus lean hyperandrogenic subgroupsto determine whether responses differ across the heterogeneous PCOS spectrum

Activation of the PI3K/AKT pathway primarily drives synapse formation and density increases, while MAPK/ERK pathway activation predominantly influences dendritic growth and arborization

Pyruvate kinase muscle isozyme M2 (PKM2) is an isoenzyme that catalyzes the conversion of phosphoenolpyruvate and ADP into pyruvate and ATP

The period of administration was variable, between the day of GnRH agonist administration [11] to 12 [12, 13] or 8 weeks before rFSH administration for Unfer et al