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Following EB administration, significant pathway enrichment was observed for nucleotide metabolism, biosynthesis of amino acids, pyrimidine metabolism, arginine and proline metabolism, and purine metabolism (Figure 5G)

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Accordingly, oxidative stress is the key threat to mitochondrial damage

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These targeting peptides are either incorporated into the biogenesis pathway of the EVs or directly loaded onto the EV membrane surface, improving the ability of the EVs to target and deliver cargo to specific tissues or cells (101)

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