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Immunogenicity: No Antibody Formation A critical safety consideration for any peptide therapy is immunogenicity, the potential to trigger immune system responses that could lead to allergic reactions, reduced efficacy through antibody neutralization, or autoimmune complications

If you need to recover quickly from an illness that depleted your B12 reserves or have recently discovered you have a B12 deficiency that is impacting your quality of life, one solution is to give your body a larger dose of B12 all at once

Clinical Trial Dosage Findings: What the Human Data Shows The Phase II clinical trials tested doses from 1 mg/day up to 10 mg/day

This can be due to a number of reasons, such as a lack of B12 in the diet, reduced stomach acidity, or when particular cells in the stomach - the "parietal" cells - do not produce enough intrinsic factor