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By enhancing cholesterol efflux that may in turn be consumed by cholesterol-rich membrane-forming regenerating oligodendrocytes, niacin would prevent prolonged lipid accumulation within macrophages and free up their phagolysosomes for further digestion of engulfed material, while also avoiding a detrimental inflammatory macrophage phenotype (Fig

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The content of the chamber was stirred by a magnetic bead and its output was flowed through the nose of the worm while it was constrained in a custommade microfluidic device