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Wu (2022YFF0710600) and the National Natural Science Foundation of China to N

The eukaryotic xenobiotic detoxification process consists of three phases: phase I (enzymes that oxidize, reduce or add hydroxyl, carboxyl or amino radicals to the xenobiotic), phase II (enzymes that conjugate molecules such as amino acids, sugars or glutathione to the xenobiotic), in which GSTs are located, and phase III (excretion of the transformed xenobiotic out of the cell) (Ames et al., 1990

Further research into the uses of BOTOX led to patients noting that their wrinkles were smoother after treatment

Figure 1 Under physiological conditions, microglia maintain central nervous system (CNS) homeostasis through a dynamic and context-dependent spectrum of functional states, traditionally described as a balance between pro-inflammatory and protective responses (Tastan and Heneka, 2024)