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The contribution of CAV-1 to angiogenesis is controversial

It has been shown that simple allometric scaling for mAbs that exhibit linear PKs in monkeys can accurately predict human PK within a twofold range.16 However, for mAbs that display nonlinear PK, due to targetmediated drug disposition, allometric scaling results in an overestimation of exposure when below targetsaturating concentrations

Association of Women Surgeons Starr Poster Session, AWS Fall Conference, 2012

This result confirms that MIA3 promotes HCC cell-induced tumour growth and that MIA3 plays a key role in HCC cell proliferation in vivo
