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The effects of rotenone on intestinal barrier integrity, colonic -synuclein levels, GFAP expression in the myenteric plexus, microglial activation in the nigrostriatal pathway, loss of dopaminergic neurons, and motor dysfunction are greatly attenuated in the presence of TLR4 (92)

For instance, certain herbal compounds such as curcumin, resveratrol, and ginsenosides have been shown to interact with key nodes such as MAPK, AKT, BACE1, and TNF- in AD networks

This combination supports enhanced recovery, sleep quality, and metabolic benefits while maintaining a well-tolerated profile

Probiotics for treatment of Clostridium difficile-associated colitis in adults