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Many therapies now considered foundational in perioperative medicine were initially adopted based on mechanistic plausibility and early observational signals before high-quality surgical outcome trials were performed

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While human clinical trials remain limited, the consistency of positive results across different injury types and animal species has generated significant interest in the biohacking and athletic communities

Untreated B12 deficiency causes peripheral neuropathy (tingling, numbness, balance issues) and, in severe cases, cognitive decline