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10.1016/j.brainres.2016.04.027 71 KenslerT

Non-mitochondrial ROS sources in diabetes Regardless of whether excessive ROS formation is the primary initiator or accompanying factor in the pathogenesis of diabetes mellitus, oxidative stress plays a key role in the organ complications such as cardiovascular problems, neurological problems (stroke), diabetic retinopathy, nephropathy, and neuropathy

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It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)