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This review will focus on the effect of metformin on the absorption of vitamin B12 and on its proposed mechanisms in hindering vitamin B12 absorption

Acknowledgments This study was financially supported by Bahar Tashkhis Teb (BT-401-12) and Royan Institute (RI-01-435)

Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation
