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Proteins, including tight junction proteins such as the claudins and occludins control paracellular permeability, defined as the conductance of water and small solutes through the spaces between adjacent epithelial cells [33, 34]

Infect Immun 71:70697078

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Because the entire pancreas is removed, the patient will: Inevitably develop insulin-dependent diabetes Absolutely require pancreatic enzyme replacement therapy Face a more complex recovery process The choice between these procedures is not a matter of patient preference but a surgical judgment made to offer the best chance of a cure, balancing the need to remove all cancer with the goal of preserving as much function as possible