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100 subjects, aged more than 40 years, participated in this trial and underwent Tesamorelin presentation daily for 6 months, followed by all absence of Tesamorelin influence for the next 6 months

This results in a loss of BBB integrity and an increase in BBB permeability, which in turn leads to increased cytokine infiltration into the central nervous system ( Figure 9 ( Figure 9 Neural signaling: Neural mechanisms of the ANS play a critical role in triggering airway hyperresponsiveness in asthma, which is predominantly mediated by the sensory vagus nerve fibers that originate from the jugular and nodose ganglia, with their axons extending peripherally into the airways and its other branches projecting centrally into the NTS in the brainstem ( The pseudonupilar neurons that constitute the sensory vagus nerve fibers are further categorized as myelinated A-fibers and unmyelinated C-fibers