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The BMP/Smad pathway effect is counteracted by the transplantation of MSCs derived from bone marrow (BMSCs), which promote NSC differentiation into OLs, the myelinating glia of the CNS (Sandner et al., 2013
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But that forced sedation comes at a cost: altered sleep architecture, next-day grogginess, tolerance development, dependency risk, and rebound insomnia when you stop taking them
