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Description
Activated T cells rely on glutamine-dependent OXPHOS to maintain energetic homeostasis under energy-related stress (e.g., low glucose levels) 137

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The presence of Akkermansia muciniphila , known to modulate BA metabolism, has also been associated with enhanced PD-1 blockade efficacy in MAFLD-related HCC, suggesting its potential as a predictive biomarker (50)

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