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The well-established anti-aging mutants, isp-1 , nuo-6, glp-1 and daf-2 , all have elevated mitochondrial superoxide 8,41
10.1016/j.tem.2018.01.002 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Sundararaghavan VL et al
Genetic Predispositions and Antioxidant Pathway Efficiency Individual genetic variation in glutathione synthesis and metabolism enzymes influences baseline antioxidant capacity
Similarly, in a pancreatic ductal adenocarcinoma subcutaneous mouse model (Pan02 tumor-bearing mice), combining attenuated Toxoplasma of the NRTUA strain with an anti-PD1 antibody significantly enhanced the antitumor activity, induced a strong immunogenic response, with effectively controlling tumor growth
