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Finch, New England Journal of Medicine 289, (1973) 10741076

This evidence reveals that the intact ETC with normal function is essential for ATP production in mitochondria and for the metabolism of energy substrates

Simultaneously, it regulates immunological synapse formation, promotes TCR signaling activation, and drives CD8 + T cells from a quiescent to an effector state

Secondly, at the gene expression level, the reduced expression of nuclear-encoded genes in the mitochondrial oxidative phosphorylation (OXPHOS) system may mediate the occurrence and development of insulin resistance in the skeletal muscle tissue of PCOS patients, and the decreased expression of PGC-1 may be a key mediating factor (Skov et al., 2007)