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The change in primacy from positive reinforcement to negative reinforcement across the addiction cycle follows neuroplastic changes in central reward neurocircuitry (e.g., the mesocorticolimbic and extended amygdala systems) induced by chronic alcohol abuse

Due to its unique biochemical function of directly reducing lipid peroxides and blocking the oxidative chain reaction on cell membranes, GPX4 is often regarded as the central barrier or gatekeeping enzyme in the ferroptosis response

GLP-1 agonists suppress appetite through peripheral gut hormone signaling and central satiety pathways

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