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Recently, studies have shown that the central nervous system (CNS) is related to the gastrointestinal tract through the brain-gut axis, which originates from the brainstem and spinal cord and innervates the intestines through the vagus nerve, splanchnic nerve, mesenteric nerve and pelvic spinal cord nerve [40, 41]

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4-( N -( S -penicillaminylacetyl)-amino)phenylarsonous acid (PENAO), a cysteine mimetic analog of the cysteine- S -conjugate metabolite of GSAO has been investigated